How Invocell Works

IVC with INVOCELL Intravaginal Culture System

An easy way to think about it is that INVOCELL is the
device used in the IVC procedure. During
IVC, your eggs
and the sperm are combined in the INVOCELL culture
device. Then, INVOCELL is
placed in your vagina, allowing
for fertilization and incubation to occur.

INVOCELL up close

INVOCELL has two parts: the culture device and
the retention device.


How IVC works with INVOCELL

Once you find a fertility specialist who offers INVOCELL, and you and your doctor have determined that IVC with INVOCELL is a good option for you, they will begin your treatment by prescribing medication to help you produce eggs. Your doctor will retrieve the eggs from your ovaries using a minimally invasive procedure during which you will be sedated. Then, your eggs will be placed with sperm. This is where the INVOCELL culture device comes in.

1

The eggs and sperm are
placed in
the culture device
for fertilization
and
incubation.

2

Your doctor will then place the
culture device
inside the
retention device, and position
them
in your vagina.
During this time, you should
avoid any strenuous physical
activity or any other
activity
that could change the
temperature of the
vagina,
such as taking a bath or using
a sauna.
Ask your doctor what
you can and can’t do while
INVOCELL is in your body.

GOOD TO KNOW: You
shouldn’t feel any
discomfort
while the device is in your
body,
but if you do, make sure
to call your doctor.

3

After this incubation period, your doctor will remove the device from your body and examine the quality and quantity of the embryos that have developed.

4

Then, your doctor will work with you to decide on
the number of embryos to be transferred to your
uterus. And the good news is, you can freeze any
remaining embryos.

In a clinical trial,

~1 IN 4 EMBRYO transfers

resulted in a birth

INDICATIONS FOR USE

INVOCELL® Intravaginal Culture System contains the INVOCELL Culture Device and INVOCELL Retention Device. The Culture Device is indicated for use in preparing, holding, and transferring human gametes or embryos during In Vitro Fertilization/Intravaginal Culture (IVF/IVC) and Intra-cytoplasmic Sperm Injection Fertilization/Intravaginal Culture (ICSI/IVC). The Retention Device is used during the incubation period to aid in holding the Culture Device in the vagina. The Culture and Retention Devices are not indicated for periods of use exceeding 72 hours.

SELECT IMPORTANT SAFETY INFORMATION

  • Do not use the Culture or Retention devices if you are unable to tolerate having a device placed within your vagina.
  • Do not use the Culture Device if you are sensitive to medical grade silicone or polystyrene or if you have a severe case of vaginitis or a history of toxic shock syndrome. Tell your doctor if you have had any recent pelvic surgery.
  • Avoid any activity such as sexual intercourse, strenuous physical activity, swimming, bathing in a tub (a shower is permissible), use of a douche, sauna, or any other activity that may alter the temperature of the vaginal cavity and avoid handling or removing the Culture and Retention Devices while in place.
  • Your doctor should explain to you what to do if the Culture and Retention Device should shift in the vagina or fall out. Call your doctor right away should this occur.

Your doctor will determine if this product is right for you and will provide you with more detailed information about the risks and benefits associated with using this device. Always follow your doctor’s instructions. Contact your doctor immediately if you have any questions or concerns before, during, or after treatment.

For more information, please see the INVOCELL Patient Information.

INDICATIONS FOR USE

INVOCELL® Intravaginal Culture System contains the INVOCELL
Culture Device and INVOCELL Retention Device. The Culture Device is
indicated
for use in preparing, holding, and transferring human
gametes or embryos during In Vitro Fertilization/Intravaginal Culture
(IVF/IVC) and
Intra-cytoplasmic Sperm Injection
Fertilization/Intravaginal Culture (ICSI/IVC). The Retention Device is
used during the incubation period to aid
in holding the Culture Device in
the vagina. The Culture and Retention Devices are not indicated for
periods of use exceeding 72 hours.

SELECT IMPORTANT SAFETY INFORMATION

  • Do not use the Culture or Retention devices if you are unable to tolerate having a device placed within your vagina.
Please see Indication and Select Important Safety Information