What is INVOCELL®?

Fertility is highly personal

  • Every couples’ needs and experiences are different, depending on who they are, where they are in their lives, and why and how they choose to address their fertility issues
  • More options are needed to assist couples along this personal journey

is a novel approach

  • INVOCELL is an IVC System that offers women and their partners another proven option on their journey to build their families
  • The INVOCELL Culture Device uses a woman’s own body as an incubator during fertilization and early embryo development


As with all ART options, IVC allows:

  • Increased control through the ability to transfer a
    single embryo
  • Additional embryos to be frozen for future use
  • Increased efficacy1


The effectiveness of INVOCELL was established in a clinical study involving 450 cycles to support US Food and Drug Administration (FDA) clearance in 2015 as the first and only IVC System.2

Proven Results

In a clinical study:

  • Adverse pregnancy outcomes, such as miscarriage and
    pre-term births, were reported in the clinical study, as these are primarily related to the effectiveness of the device (ie, the clinical pregnancy and live birth rates)
REFERENCES: 1. Cohn HR, Wellock C, Miller BT, et al. Analysis of 215,212 ovulation induction (OI) and intrauterine, insemination (IUI) cycles reveals the high rate of multiple gestations, in patients across age groups and diagnoses. Human Reproduction, supplement 1 33:i294-i295. 2. INVOCELL Intravaginal Culture System [instructions for use], Medfords, MA: INVO Bioscience.

Who is INVOCELL® for?


Those who want a
treatment that offers greater
efficacy than Intrauterine
Insemination (IUI)1


Those who are cost
conscious and seeking
alternative options


Those who may need to
limit travel to, or frequency
of, physician visits


Those who want to be
more involved and are
looking for incubation to
occur within the body as
opposed to in a laboratory


Those seeking an
alternative to IVF for
religious or cultural

How does INVOCELL® work?

The patient undergoes a mild ovarian
stimulation and monitoring cycle.


Once the eggs are retrieved
and sperm is collected, they
are placed into the INVOCELL
Culture Device.*


The device is then
immediately placed in the
vaginal cavity to allow
fertilization and incubation
to take place.


Upon completion of the
incubation period, the device
is removed.


An embryo is selected
for transfer into the uterus.
Any additional embryos
can be frozen.

*An ICSI may be recommended prior to placement in the device.

REFERENCE: INVOCELL Intravaginal Culture System [instructions for use]. Medford, MA: INVO Bioscience.

Want to offer INVOCELL at your clinic?

Submit the information below, and a representative will be in touch with more details on training.

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Providing a
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approaches to
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informational brochure to share with your patients


  • Culture and Retention Devices should not be used in patients with the inability to tolerate placement or wearing of a device within the vaginal cavity.
  • Culture and Retention Devices are single use only. Do not use if product or package appears damaged.
  • Do not use Culture Device in patients with hypersensitivity to medical grade silicone or polystyrene or in patients with a severe case of vaginitis or with a history of toxic shock syndrome. Evaluate patients for any recent pelvic surgery to assure it will not affect intravaginal culture procedure.
  • Proper handling is extremely important to safe and effective use of Culture Device. Do not begin clinical use of INVOCELL Intravaginal Culture System without establishing competency by reading and practicing Instructions for Use.
  • It is recommended that INVOCELL Intravaginal Culture System be utilized with a mild ovarian stimulation protocol. The recommended upper limit on number of oocytes or ICSI fertilized embryos to be placed in Culture Device is seven.
  • Verify Culture Device is correctly locked before placement in vaginal cavity.
  • Patients should avoid any activity that may alter temperature of vaginal cavity and should avoid manipulation and removal of Culture and Retention Devices while in place.

Please see the full INVOCELL Intravaginal Culture System Instructions for Use for more detailed information.


INVOCELL® Intravaginal Culture System consists of the INVOCELL Culture Device and the INVOCELL Retention Device. The Culture Device is indicated for use in preparing, holding, and transferring human gametes or embryos during In Vitro Fertilization/Intravaginal Culture (IVF/IVC) and Intra-Cytoplasmic Sperm Injection Fertilization/ Intravaginal Culture (ICSI/IVC) procedures. The Retention Device is indicated for use during the incubation period to aid in retention of the Culture Device in the vaginal cavity. The Culture and Retention Devices are not indicated for incubation periods exceeding 72 hours.


  • Culture and Retention Devices should not be used in patients with the inability to tolerate placement or wearing of a device within the vaginal cavity.
  • Culture and Retention Devices are single use only. Do not use if product or package appears damaged.
Please see Indication and Select Important Safety Information